New PDF release: Arteriosclerosis: New Insights into Pathogenetic Mechanisms

By Prof. Dr. W. Hort (auth.), Prof. Dr. H. Just, Prof. Dr. W. Hort, PD Dr. A. M. Zeiher (eds.)

ISBN-10: 3642856608

ISBN-13: 9783642856600

ISBN-10: 3642856624

ISBN-13: 9783642856624

A immense literature has been excited by arteriosclerosis and but, many points of pathogenesis and of the mechanism of improvement of the arteriosclerotic vascular lesion stay basically poorly understood. lately, our wisdom of the earliest levels of arteriosclerosis have enormously better. through now, we have now discovered to narrate morphologic adjustments to disturbances in functionality. it's been of specific impor­ tance that elements of the arterial wall should be analyzed in regard to disorder, for instance, within the endothelium or the vascular delicate muscle. The interplay of the several morphological parts of the vascular wall may well hence be a lot wager­ ter understood. Likewise, the interplay among the arterial wall and the flowing blood may be far better defined, together with the intimate dating among platelets and the endothelium, the coagulation process and the endothelium, the granulocytes and the endothelial mobilephone layer, in addition to techniques of migration of blood cells into the subendothelial area. the popularity of practical and morphological disturbance has attained scientific value not just as the arteriosclerotic illnesses have quantitatively reached the scale of a plague, that's, of a importance by no means been witnessed. it's also due to the improvement of latest medicinal drugs that intrude with the atherogenic method and thereby hinder the advance of the sickness or halt its development. it's also turning into more and more attainable to inhibit the prevalence of problems in current arteriosclerotic lesions in show up sickness, i. e.

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Additional resources for Arteriosclerosis: New Insights into Pathogenetic Mechanisms and Prevention

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If that turns out to be the case, antibodies to such antigens might be useful diagnostic markers of the disease. If immune responses to oxidized lipoproteins are important in atherosclerosis, one would expect them to be initiated in the atherosclerotic plaque where the concentration of oxidized lipoproteins is high. If that is the case, some of the Tlymphocytes present in the plaque may recognize oxidation-induced epitopes on local lipoproteins. Recent molecular analyses of antigen receptor genes in plaque Tlymphocytes have shown that these cells represent heterogeneous immune responses and not a few clones directed against a small number of epitopes (30).

In: Paoletti R, Gotto AM, Jr (eds). Atherosclerosis Reviews, vol. 1, Raven Press, New York, pp 119-136 28. Spring PM, Hoff HF (1989) LDL accumulation in the grossly normal human iliac bifurcation and common iliac arteries. Exp Mol Pathol51: 179-185 29. Stary HC (1974) Proliferation of arterial cells in atherosclerosis. In: WagnerWD, Clarkson TC (eds). Arterial mesenchyme and arteriosclerosis. Plenum Press, New York, Adv Exp Med Bioi 43: 59-81 30. Stary HC (1987) Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children.

J Cell Bioi 67: 660-674 31 37. Wright HP (1968) Endothelial mitosis around aortic branches in nonnal guinea pigs. Nature 220:7&-79 38. Yarnell JWG, Baker lA, Sweetnam PM, Bainton D, O'Brien JR, Whitehead PJ, Elwood PC (1991) Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. Circulation 83: 836-844 39. Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S (1983) Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.

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Arteriosclerosis: New Insights into Pathogenetic Mechanisms and Prevention by Prof. Dr. W. Hort (auth.), Prof. Dr. H. Just, Prof. Dr. W. Hort, PD Dr. A. M. Zeiher (eds.)


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