By Jonathan A. Cotliar
This atlas offers trainees and practising physicians a visible toolkit to assist realize and deal with this tough thoroughly. this article highlights the scientific variability of GVHD, and hands readers with the diagnostic clues to categorize sufferers in accordance with the present grading/staging guidance. additionally, this atlas deals evidence-based diagnostic and therapy algorithms for physicians to take advantage of whereas at sufferers' bedsides.
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Extra resources for Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment
A) Acute ocular GVHD can present with pseudomembranous conjunctivitis and sloughing of the cornea, which can be visualized using fluorescein dye staining or slit lamp examination. (b) Complete loss of eyelashes may also be seen in the setting of acute ocular GVHD. (c) In chronic ocular GVHD, punctate keratopathy involving the cornea and conjunctiva can be seen in the setting of keratoconjunctivitis sicca, or dry eye syndrome, and can be visualized with the aid of dyes including fluorescein, lissamine green (as shown), and rose Bengal.
2016. pii: blood-2016-02-702852. [Epub ahead of print]. 25. Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med. 2013;5(179):179ra143. 26. She K, Gilman AL, Aslanian S, Shimizu H, Krailo M, Chen Z, et al. Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease. Biol Blood Marrow Transpl.
2014;28:915–24. Clinical differentiation of acute cutaneous graft-versus-host disease from drug hypersensitivity reactions. J Am Acad Dermatol. 2011;65:726–32. Approach to the morbilliform eruption in the hematopoietic transplant patient. Semin Cutan Med Surg. 2007;26:155–62. Pathogenesis and clinical manifestations of graft-versushost disease. e1–18; quiz 533–4. Acute follicular graft-vs-host reaction. A distinct clinicopathologic presentation. Arch Dermatol. 1988;124:688–91. Atypical manifestations of graft-versus-host disease.
Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment by Jonathan A. Cotliar