By Joseph Wheat (auth.), Gerald L. Mandell MD, Richard D. Diamond MD (eds.)
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5. 16. Thornberry DK. Wheat LJ. 8randt KD. Rosenthal J: Histoplasmosis presenting withjoint pain and hilar adenopathy: pseudosarcoidosis. Arthritis Rheum 1982. 25:1396-1402. Williams 8, Fojtasek M, Connolly-Stringfield P. Wheat J: Diagnosis of histoplasmosis by antigen detection during an outbreak in lndianapolis. Ind. Arch Pathol Lab Med 1994, 118:1205-1208. 17. Wheat LJ, Kohler R8, Tewari RP: Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens.
The number of reported cases has increased steadily. The reasons for this continued increase are not clear. but the largest impact of cases is occurring in the region encompassing the two largest cities in Arizona. Phoenix and Tucson. (Courtesy ofDr. ) FtGURE 2-7. Life cycle of Coccidioides immitis. The life cycle of the fungus occurs in two phases. , C. immitis exists as a mold in which alternating cells degenerate. leaving barrel-shaped arthroconidia that can become airborne. When inhaled int o the lung, arthroconidia undergo profound morphologic changes.
1O. Pappagianis D: Coccidioides immitis. In Topley & Wilson's Microbiology and Microbiallnfections voi 4. edn 9. Edited by Ajello L. Hays RJ. Collier L. et al. London: Arnold; 1998:357-371. Pappagianis D: Coccidioidomycosis. In Laboratory Diagnosis of lnfectious Diseases: Principles and Practice voi 1. Edited by Balows A. Ha usier WJ. Ohashi M. Tur ano A. New York: Springer Verlag; 1988:618. SELECTED BIBLIOGRAPHY Drutz DJ. Catanzaro A: Coccidioidomycosis: parts 1 and Il. Am Rev Respir Dis 1978.
Atlas of Infectious Diseases: Fungal Infections by Joseph Wheat (auth.), Gerald L. Mandell MD, Richard D. Diamond MD (eds.)