By Matt Kalaycio
The Cleveland health center beginning, OH. textual content covers information regarding new biologic cures and gives the health care professional with sensible facts for treating sufferers with leukemia. Discusses such remedies as arsenic trioxide, P-glycoprotein inhibitors, and interleukins. additionally covers genetic code changes. DNLM: Leukemia, treatment.
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Additional info for Biologic Therapy of Leukemia
All patients who achieved a complete or an excellent partial response achieved 100% T-cell chimerism. Several conclusions can be drawn from this data. First, the preparative regimen described is associated with limited early toxicity and reduced treatmentrelated mortality compared with an ablative allogeneic transplantation. Peripheral blood–nucleated cell chimerism develops rapidly. Complete T-cell chimerism appears to be a requirement for an ongoing disease response, although the development of complete T-cell chimerism does not guarantee absence of progressive disease.
Long-term follow-up of patients who achieved complete remission after donor leukocyte infusions. Biol Blood Marrow Trans 1999;5:253–261. 51. Dazzi F, Szydlo R, Cross N, et al. Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Blood 2000;96:2712–2716. 52. Collins R, Goldstein S, Giralt S, et al. Donor leukocyte infusions in acute lymphocytic leukemia. Bone Marrow Trans 2000;26:511–516. 53.
Blood 1999;93:4071–4078. 34. Hsieh M, Korngold R. Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses. Blood 2000;96:1047–1055. 35. Jiang Y, Kanfer E, Macdonald D, et al. Graft-versus-leukaemia following allogeneic bone marrow transplantation: emergence of cytoxic T lymphocytes reacting to host leukaemia cells. Bone Marrow Trans 1991;8:253–258. 36. Bertheas M, Lafage M, Levy P, et al. Influence of mixed chimerism on the results of allogeneic bone marrow transplantation for leukemia.
Biologic Therapy of Leukemia by Matt Kalaycio