Read e-book online Biological Responses in Cancer: Progress toward Potential PDF

By George J. Todaro, Hans Marquardt, Daniel R. Twardzik (auth.), Enrico Mihich (eds.)

ISBN-10: 1468446827

ISBN-13: 9781468446821

ISBN-10: 1468446843

ISBN-13: 9781468446845

The sequence of volumes entitled organic Responses in melanoma: growth towards capability functions offers details on ways during which the interplay among neoplastic and basic cells can be converted. every one annual quantity comprises contributions in components the place major prog­ ress has been made. issues to be handled comprise immunologic and host safety platforms, regulate mechanisms of mobile and inhabitants progress, mobile differentiation, and phone transformation. The regulatory mechanisms controlling the interactions among common and tumor cells can be immunologic in nature or they could relate to different organic features of tumor and basic cells and their reaction to micro environmental components. whereas the imperative query of tumor immunol­ ogy addresses the character and strong point of tumor-associated antigens in people, the id of the phases of differentiation and services of a number of the phone kinds all for immunity is advancing swiftly. The de­ velopment of monoclonal antibody methodologies, including development within the biochemical characterization of phone markers, mobilephone separation, and size of phone services, has considerably aided within the identity and quantitation of other mobilephone kinds. setting up the function of those cells within the rules of human immune mechanisms deals a method for evalu­ ating the prestige of the immune responses in melanoma sufferers and for assessing the results that tumor and antitumor remedies may perhaps exert on their func­ tionality, which, in flip, may well modify the results of antitumor treatments.

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1982, T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALBand Harvey-MSV transforming genes, Nature 298:343-347. Savage, C. , Hash, J. , 1973, Epidermal growth factor. Location of disulfide bonds, J. BioI. Chern. 248:7669-7672. , 1982, Nucleotide sequence of Fujinami sarcoma virus: Evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses, Cell 30:787-795. Shih, T. , Papageorge, A. , Stokes, P. , Weeks, M. , and Scolnick, E.

1976, Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor (EGF) to cells, Nature 264:26-31. Todaro, G. , and De Larco, J. , 1980, Transforming growth factors produced by certain human tumor cells: Polypeptides that interact with epidermal growth factor receptors, Proc. Natl. Acad. Sci. USA 77:5258-5262. 18 GEORGE J. TODARO et 01. Todaro, G. , De Larco, J. , Reynolds, F. , and Stephenson, J. , 1981, Transforming growth factors produced by human tumor cells: Interactions with epidermal growth factor (EGF) membrane receptors, in: Cellular Responses to Molecular Modulators (W.

Fever) when given intramuscularly. This would imply that gamma IFN can induce systemic side effects without HETEROGENEITIES OF HUMAN INTERFERONS 37 getting into the bloodstream, which is not the situation with beta IFN. Clearly more data are needed before any conclusions' can be drawn. 6. PRACTICAL CONSIDERATIONS CONCERNING HUMAN IFN TYPES AND SUBTYPES In rationally planning clinical trials with the IFNs (and other biological response modifiers), it would be desirable to have data available to allow one to make decisions on such questions as the following: • • • • Which IFN should be used for the disease in question?

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Biological Responses in Cancer: Progress toward Potential Applications by George J. Todaro, Hans Marquardt, Daniel R. Twardzik (auth.), Enrico Mihich (eds.)

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