Get Blue Biotechnology: From Gene to Bioactive Product PDF

By Werner E. G. Müller, Heinz C. Schröder, Xiaohong Wang

ISBN-10: 331951282X

ISBN-13: 9783319512822

ISBN-10: 3319512846

ISBN-13: 9783319512846

This booklet describes the invention of molecules from unexploited severe marine environments, and offers new ways in marine genomics. It combines the present country of data in marine genomics and complicated typical items’ chemistry to pursue the sustainable creation of novel secondary metabolites (lead compounds), in addition to pharmacologically energetic peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating results. additional, it employs molecular-biology-based methods and complex chemical strategies to acquire and to pick candidate compounds for pre-clinical and scientific studies.

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1211/0022357011775712 Höller U, König GM, Wright AD (1999) Three new metabolites from marine-derived fungi of the genera Coniothyrium and Microsphaeropsis. J Nat Prod 62(1):114–118. 1021/ np980341e Holzwarth M, Trendel J-M, Albrecht P, Maier A, Michaelis W (2005) Cyclic peroxides derived from the marine sponge Plakortis simplex. J Nat Prod 68(5):759–761. 1021/np049665v Hougaard L, Christophersen C, Nielsen PH, Klitgaard A, Tendal O (1991) The chemical composition of species of Geodia, Isops and Stryphnus (Choristida: Demospongia: Porifera): a comparative study with some taxonomical implications.

3732/ajb. 1737 Andersson L, Bano S, Bohlin L, Riccio R, Minale L (1985) Studies of the Swedish marine organisms. Part 6. A Novel bioactive steroidal glycoside from the starfish Crossaster papposus. J Chem Res (12):366–367 Andersson L, Lidgren G, Bohlin L, Magni L, Ogren S, Afzelius L (1983) Studies of Swedish marine organisms. I. Screening of biological activity. Acta Pharm Suec 20(6):401–414 Andersson L, Lidgren G, Bohlin L, Pisa P, Wigzell H, Kiessling R (1986) Studies of Swedish marine organisms.

However, corroborating evidence was provided by a sequence found in the metatranscriptome of G. barretti (Radax et al. 2012). The final sequences of barrettide A and B could thus be determined (Fig. 4). No homologues to these peptides could be found when searching the NCBI databases for similar sequences (Carstens et al. 2015). The three-dimensional structure in solution of barrettide A was determined using NMR. The peptides adopt a long β-hairpin-fold cross-braced by the two disulfide bonds. Both peptides—they differ only with a valine to leucine substitution—are amphipathic in nature: the hydrophobic and charged residues cluster on separate faces of the molecule.

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Blue Biotechnology: From Gene to Bioactive Product by Werner E. G. Müller, Heinz C. Schröder, Xiaohong Wang


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