By Richard E. Champlin (auth.), Richard Champlin M.D. (eds.)
Bone marrow transplantation has emerged as a big type of remedy for a vast variety of human ailments. Marrow transplantation has many special biologic positive factors and its ideas fluctuate markedly from the transplantation of reliable organs. This quantity overviews the current prestige of bone marrow transplantation and summarizes contemporary growth and controversies. advert vances in defining the underlying biology of marrow transplantation are mentioned. the present prestige of a number of significant scientific troublesome areas are reviewed, together with engraftment, acute and persistent graft-versus-host dis ease, immunodeficiency, and opportunistic infections. The healing position of allogeneic and autologous bone marrow transplantation is mentioned, and effects are in comparison with substitute cures. lX record of participants ANASETII, CLAUDIO, M. D. , Fred Hutchinson melanoma examine heart, 1124 Columbia highway, Seattle, Washington 98104 APPELBAUM, FRED, M. D. , Fred Hutchinson melanoma study heart, 1124 Columbia highway, Seattle, Washington 98104 ARMITAGE, JAMES zero. , M. D. , division of inner drugs, Univer sity of Nebraska scientific middle, forty second and Dewey road, Omaha, Nebraska 68105 BEATIY, PATRICK G. , M. D. , Fred Hutchinson melanoma learn heart, 1124 Columbia road, Seattle, Washington 98104 BIERMAN, PHILIP J. , M. D. , division of inner drugs, Univer sity of Nebraska clinical heart, forty second and Dewey street, Omaha, Nebraska 68105 BUTTURINI, ANNA, M. D. , division of Pediatrics, college of Parma university of medication, Parma, Italy CHAMPLIN, RICHARD, M. D.
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Blood 1985; 65:392. Blazar BR, Widmer MB, Soderling CCB, Urdal DL, Gillis S, Robison LL, Vallera DA. Augmentation of donor bone marrow engraftment in histocompatible murine recipients by granuloctye/marcophage colony-stimulating factor. Blood 1988; 71:320. Samlowski WE, Daynes RA. Bone marrow engraftment efficiency is enhanced by competitive inhibition of the hepatic asialoglycoprotein receptor. Proc Nat! Acad Sci USA 1985; 82:2508. Or R, Weshler Z, Lugassy G, Steiner-Salz D, Galun E, Weiss L, Samuel S, Po Iliac A, Rachmilewitz EA, Waldmann H, Slavin S.
Surface IgG, IgM, IgA, and IgD staining of B cells from marrow recipients who received T-cell-containing grafts showed that certain marrow graft recipients did not have sIgG- or sIgA-bearing B cells . Others have shown that B cells from recipients had higher numbers of primitive-IgM determinants per B cell than normal B cells . Recent data from UCLA show a dissociation between B-cell phenotypes and functions . Recipients who received T-cell-depleted grafts at MCW show increased proportions of sIgMand sIgD-bearing B cells.
An exciting, new area will be the insertion of specific genes into the marrow inoculum or into specific lymphocyte subsets to reconstitute specific immune defects. This approach, combined with the use of recombinant molecules to regulate or enhance the growth of certain cell populations, may allow the clinician to accelerate and control the process of immune reconstitution. Acknowledgments This work was supported in part by funds from the Division of Hematology and Oncology, Departments of Medicine and Pediatrics, Medical College of Wisconsin.
Bone Marrow Transplantation by Richard E. Champlin (auth.), Richard Champlin M.D. (eds.)