By Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni
This publication provides updated info on one of many preferred themes in prostate melanoma, particularly bone metastases. the latest advancements with recognize to biology, pathology, analysis, and remedy are defined, supplying readers with an exceptional knowing of the mechanisms of metastasis formation, the features of metastases, their aggressiveness, and prognostic components for therapy reaction. The assurance contains dialogue of all the most sensible on hand concepts (laboratory, radiology, and nuclear medication) for attaining early prognosis and either validated and novel healing techniques. specific info is supplied on hormonal manipulations, bone-targeted brokers, vaccines, taxanes, and different remedies which are enriching the healing armamentarium. The editors might be thought of leaders within the box, with nice event in diagnostic and scientific oncology and study, and the authors are specialists in assorted specialties. This guarantees a multidisciplinary strategy, mirroring the present scenario within which remedy in sufferers with bone metastases is undertaken by means of a workforce of experts and overall healthiness execs in quite a few fields.
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Additional info for Bone Metastases from Prostate Cancer : Biology, Diagnosis and Management
Am J Cancer Res 1(1):71–84 Shiota M, Itsumi M, Takeuchi A, Imada K, Yokomizo A, Kuruma H, Inokuchi J, Tatsugami K, Uchiumi T, Oda Y, Naito S (2015) Crosstalk between epithelialmesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer. Endocr Relat Cancer 22(6):889–900 Fournier PG, Juárez P, Jiang G, Clines GA, Niewolna M, Kim HS et al (2015) The TGF-β signaling regulator PMEPA1 suppresses prostate cancer metastases to bone. Cancer Cell 27(6):809–821 Haider M, Zhang X, Coleman I, Ericson N, True LD, Lam HM, Brown LG, Ketchanji M, Nghiem B, Lakely B, Coleman R, Montgomery B, Lange PH, Roudier M, Higano CS, Bielas JH, Nelson PS, Vessella RL, Morrissey C (2016) Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases.
63. 64. 65. 66. and activating TWIST1. Cancer Res 75(15): 3077–3086 Wang L, Song G, Tan W, Qi M, Zhang L, Chan J, Yu J, Han J, Han B (2015) MiR-573 inhibits prostate cancer metastasis by regulating epithelial-mesenchymal transition. Oncotarget 6(34):35978–35990 Li X, Liu Y, Wu B, Dong Z, Wang Y, Lu J et al (2014) Potential role of the OPG/RANK/RANKL axis in prostate cancer invasion and bone metastasis. Oncol Rep 32(6):2605–2611 Hall CL, Kang S, MacDougald OA, Keller ET (2006) Role of Wnts in prostate cancer bone metastases.
Zhau HE, Odero-Marah V, Lue H-W et al (2008) Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model. Clin Exp Metastasis 25(6):601–610 19. Josson S, Sharp S, Sung S-Y et al (2010) Tumor-stromal interactions influence radiation sensitivity in epithelialversus mesenchymal-like prostate cancer cells. J Oncol 2010:10. 232831 20. Conley SJ, Gheordunescu E, Kakarala P et al (2012) Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
Bone Metastases from Prostate Cancer : Biology, Diagnosis and Management by Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni