By Eggert Stockfleth MD PhD, Darrell S. Rigel MD, June K. Robinson MD, Merrick I. Ross MD, Robert Friedman MD MSc (Med), Clay J Cockerell, Henry Lim MD, John M Kirkwood MD
Cancer of the Skin, edited by means of Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is the complete, multimedia advisor to early prognosis and potent scientific and surgery of cancer and different pores and skin cancers. completely up-to-date with eleven new chapters, this broad-based, accomplished reference offers you the newest details on scientific genetics and genomics of dermis melanoma, certain treatment for cancer, the diet D debate about the dangers and merits of sunlight publicity, and different well timed subject matters. a brand new, multi-disciplinary workforce of individuals and editors created from major specialists during this box deals actually different views and around the globe most sensible practices.
- Broaden your realizing of all points of epidermis cancer-from the underlying biology to medical manifestations of the illness to analysis, and clinical and surgical treatment-with this easy-to-use, entire, multimedia reference.
- See stipulations as they seem in perform with advice from specific full-color photographs and step by step procedural video clips.
- Stay present with the most recent developments and remedies! eleven new chapters hide scientific genetics and genomics of dermis melanoma, specific treatment for cancer, the diet D debate about the hazards and advantages of sunlight publicity, and different crucial topics.
- Get actually different views and around the globe top practices from a brand new, multi-disciplinary crew of individuals and editors made from the world’s major specialists
Access the whole textual content online-including photo financial institution and video library-at www.expertconsult.com
Diagnose epidermis melanoma successfully utilizing a multimedia reference with a multi-disciplinary strategy and the newest content material and techniques.
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Additional info for Cancer of the Skin: Expert Consult - Online and Print, 2e
2009;459(7250):1085–1090. 85. Garraway LA, Widlund HR, Rubin MA, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436(7047):117–122. 86. Kim M, Gans JD, Nogueira C, et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 2006;125(7):1269–1281. 87. Pollock PM, Trent JM. The genetics of cutaneous melanoma. Clin Lab Med. 2000;20(4):667–690. 21 Part 1 Chapter 2 • Genetics of Skin Cancer 8 8. Holland EA, Beaton SC, Edwards BG, et al.
Melanocytes contain a unique lysosome-related intracytoplasmic organelle, the melanosome, which is the site of melanin biosynthesis. • Compared with lightly pigmented skin, darkly pigmented skin has more numerous, larger melanosomes that contain more melanin; once transferred to keratinocytes, the melanosomes of darkly pigmented skin are singly dispersed and degraded more slowly. • Tyrosinase is the key enzyme in the melanin biosynthetic pathway. • Two major forms of melanin are produced by melanocytes: brown-black, photoprotective eumelanin and yellow-red, photolabile pheomelanin.
J Cell Biol. 1999;147(1):71–76. 18. Adolphe C, Hetherington R, Ellis T, et al. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. 2006;66(4):2081–2088. 19. Barnes EA, Kong M, Ollendorff V, et al. Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. 2001;20(9):2214–2223. 20. Zhang H, Ping XL, Lee PK, et al. Role of PTCH and p53 genes in earlyonset basal cell carcinoma. Am J Pathol. 2001;158(2):381–385. 21. Ping XL, Ratner D, Zhang H, et al.
Cancer of the Skin: Expert Consult - Online and Print, 2e by Eggert Stockfleth MD PhD, Darrell S. Rigel MD, June K. Robinson MD, Merrick I. Ross MD, Robert Friedman MD MSc (Med), Clay J Cockerell, Henry Lim MD, John M Kirkwood MD