By H. Hampl, A. Besarab
Uremia, that is linked to the deterioration of renal functionality, is a fancy procedure that affects all cardiac buildings. an important manifestations of this ailment are hypertensive and anemic middle sickness, coronary artery affliction and middle valve illnesses. Cardiovascular illnesses are hence the first explanation for dying in sufferers on hemodialysis. This booklet provides suggestions to seriously decrease cardiac morbidity/mortality in uremic sufferers. the subjects comprise the function of oxidative pressure (caused via anemia) in cardiovascular harm and the correction of anemia via erythropoietin. This correction additionally considerably reduces elevated oxidized lipoprotein species, key components of arteriosclerosis. one other possibility issue that is mentioned is serious left-ventricular hypertrophy (LVH), which predisposes ventricular arrhythmia prompted by way of severely decreased coronary reserve, usually resulting in surprising demise
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Extra resources for Cardiovascular disease in the uremic patient : cardio-nephrology symposium
A similar investigation on the correction of renal anemia in relation to oxidative stress was carried out by a collaborating group at the University of Nis, where the plasma MDA changes in 20 patients (53 8 10 years) were measured after 1 year of eopetin treatment. Determination of HNE, MDA and Protein Carbonyls The measurement of HNE includes modiﬁcation of this aldehyde with dinitrophenylhydrazine, chromatographic analysis of the dinitrophenylhydrazones in three groups, and, ﬁnally, isocratic analysis of the dinitrophenylhydrazine derivates of the 4-hydroxyalkenales [22–24].
2. Individual concentrations of serum 5 HNE in patients with chronic renal failure and in controls. Values from 107 patients and 80 controls. In 56 patients from AUSL-LE Scorrano/Lecce, the oxidative stress was observed after treatment with epoetin to increase Hb values. Two years after starting epoetin therapy for renal anemia, the oxidative stress parameters in 56 patients were re-evaluated and compared with the pretreatment values. A similar investigation on the correction of renal anemia in relation to oxidative stress was carried out by a collaborating group at the University of Nis, where the plasma MDA changes in 20 patients (53 8 10 years) were measured after 1 year of eopetin treatment.
Seeing that the oxysterol levels are in fact increased in ESRD patients undergoing HD, but that the absolute values of oxysterols and the ratio between summarized oxysterols and cholesterol ranges from 4 to 15‰, one should assume that direct chemical reactions stimulating plaque formation or initiating further changes in favor to atherosclerosis can only be due to a long-lasting chronic effect because of the low levels of these compounds. On the other hand, signaling effects of oxysterols, contributing to increased risk of atherosclerosis and further cardiovascular diseases, might be involved.
Cardiovascular disease in the uremic patient : cardio-nephrology symposium by H. Hampl, A. Besarab