By Jim E. Riviere, Nancy A. Monteiro-Riviere
Many experimental equipment and mathematical modeling ways rooted in disciplines outdoors of toxicology should be successfully utilized to estimating dermal absorption. Dermal Absorption versions in Toxicology and Pharmacology explores present methods and methods that may be used to quantify dermal absorption with endpoints necessary in either toxicology and pharmacology.
The ebook starts with a assessment of easy ideas and the in vitro and in vivo experimental methods on hand for assessing dermal absorption of substances and chemical compounds. this can be through insurance of mathematical or in silico types for quantitating percutaneous absorption and the functions of those ideas to the chance evaluate technique. the rest of the e-book explores eventualities the place the original homes of the chemical substances being studied or the matrix during which they're uncovered needs to be thought of after which wraps up with a comparative research of chemical permeability in human and animal skin.
Many of the books protecting this topic are only too entire and serve essentially as reference works. This publication takes a unique procedure. Jim Riviere's editorial suggestions guarantees that the data is readable, available, authoritative, and concise, making it the proper source for familiarizing new researchers and scholars to the sphere and updating confirmed scientists.
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Additional resources for Dermal Absorption Models in Toxicology and Pharmacology
Invest. , 84:180–183. L. , 1984, Methods for in vitro percutaneous absorption studies III: hydrophobic compounds, J. Pharm. , 73:1255–1258. L. , 1985, Methods for in vitro percutaneous absorption studies IV: the flow-through diffusion cell, J. Pharm. , 74:64–67. , 1986, Methods for in vitro percutaneous absorption studies VI: preparation of the barrier layer, J. Pharm. , 75:487–491. , 1986, Methods for in vitro percutaneous absorption studies VII: use of excised human skin, J. Pharm. , 75:1094–1097.
RECEPTOR FLUID In vitro skin absorption studies often differ in the receptor fluid used. , 1989). , 1989). Modifications of the receptor fluid are sometimes made to facilitate the partitioning of lipophilic chemicals from skin into the receptor fluid to simulate the 24 DERMAL ABSORPTION MODELS IN TOXICOLOGY AND PHARMACOLOGY in vivo absorption process. The addition of 3 to 5% bovine serum albumin is a mild, more physiological adjustment that can be useful but often does not provide sufficient lipid solubility to the receptor fluid (Bronaugh and Stewart, 1986).
1 IPPSF vs. 7 PERFUSED SKIN MODELS 37 In vivo human (% dose) IPPSF vs. 91 0 5 10 15 20 25 IPPSF (% dose) 30 35 40 IPPSF-predicted vs. human availabilities for 16 compounds for which comparable experimental conditions (dose/unit area, vehicle) for both data sets were available. 4. 91) between absorption determined in IPPSFs compared to humans. Dermatopharmacokinetic Studies The greatest level of precision that may be achieved with this system is to apply pharmacokinetic models either to extrapolate to the in vivo situation or to quantitate the fate of the drug within the skin.
Dermal Absorption Models in Toxicology and Pharmacology by Jim E. Riviere, Nancy A. Monteiro-Riviere