By Ronald Marks, James J. Leyden
This article bargains the busy dermatologist an updated assessment of advancements within the administration and therapy of dermatologic issues. Dermatologic remedy in present perform explores not just the study theories that experience lately emerged, but additionally the sensible program of that examine in ordinary medical perform. quite a number issues is explored, together with new drug cures, surgical advances and the administration of sure universal dermis difficulties, akin to psoriasis, rosacea, epidermis melanoma and pimples. This quantity is integral for each dermatologist, health practitioner and plastic health care professional, and it truly is invaluable for complex scholars in dermatology.
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This article deals the busy dermatologist an updated evaluate of advancements within the administration and therapy of dermatologic problems. Dermatologic treatment in present perform explores not just the learn theories that experience lately emerged, but in addition the sensible program of that study in commonplace scientific perform.
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Additional info for Dermatologic therapy in current practice
Peck GL, Olsen TG, Yoder FW, Prolonged remissions of cystic conglobate acne with 13-cis-retinoic acid. N Engl J Med 1979: 300; 329–33. 17. Strauss JS, Stranieri JS, Farrell LN, The effect of marked inhibition of sebum production with 13-cis-retinoic acid on skin surface lipid composition. J Invest Dermatol 1980: 74; 66–7. 18. King K, Jones DH, Daltry DC, Cuncliffe WJ, A double-blind study of the ch03 7/9/01 44 11:01 am Page 44 Dermatologic Therapy in Current Practice effects of 13-cis-retinoic acid on acne, sebum excretion rate and microbial population.
Engui EM, Mirkovitch A, Allison AC, Lymphocyte-selective anti-proliferative and immunosuppressive effects of mycophenolic acid in mice. Scand J Immunol 1991: 33; 175–83. ch02 7/9/01 11:01 am Page 33 Management approaches to atopic dermatitis 33 51. Kitchen JE, Pomeranz MK, Pak G et al, Rediscovering mycophenolic acid: a review of its mechanism, side-effects and potential uses. J Am Acad Dermatol 1997: 37; 445–9. 56. Hanifin JM, Chan SC, Cheng JB et al, Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis.
51 No significant benefit was seen in a recent small open trial of mycophenolate mofetil52 and clearly randomized controlled studies are necessary. Interferon gamma (IFN-␥) Anti-inflammatory agents This is a cytokine produced primarily by T cells with a Th0/Th1 profile which plays an important regulatory role in immune function. IFN-␥ promotes proliferation of Th1 cells and decreases IgE levels and eosinophil counts. Subcutaneous IFN-␥ does reduce the severity These include antihistamines (mentioned earlier), UV radiation which also has a recognized place in non-refractory AD, phosphodiesterase inhibitors, leukotriene receptor antagonists, thalidomide and thymopentin.
Dermatologic therapy in current practice by Ronald Marks, James J. Leyden