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Extra resources for Deutsche Pharmakologische Gesellschaft: Abstracts of the 18. Spring Meeting
C and tc for D. 4. cating a coii1JTion mechanism of action of 1. "'ithe2+ glycoside and of 2. ssen, Hufelandstr. 9912}. The results support the thesis that inhibition of active cation tranapart is an important step in glycoside induced positive inotropic effect. Medizinische Abteilung, Bundeswehrzentralkrankenhaus, Postfach 746o, S4oo Koblenz 106 108 CH4RACTERISATTON OF DIFFERBNT TYPE~<; OF CAHDIAC GLYCOSTnE HECEPTOHS IN RAT AND GUINEA PIG llEAHT. E. Erdmann, G. Philipp, and W. AL STRIPS S. Holzmann, G.
Department of Toxicology, University of the Saarland, D6650 Homburg/Saar, W-Germany 126 CARDIOPULMONARY EFFECTS OF ACUTE AORTIC OBJ. SCULAR EFFECTS OF SOME DOPAMINE DERIVATIVES. P. -w. Dreyer, E. Westerrnann In rnongrel dogs anaesthetized with a-chloralose a balloon catheter was introduced suprarenally via the fernoral artery into the abdominal aorta and an increase of 100 % in wedge pressure produced by inflating the balloon over a period of 20 rninutes. The occlusion of the aortawas followed by an increase in rnean aortic pressure and bronchial resistance; o 2 partial pressure in the arterial blood (Pa02 J rose by 10-12 %.
Ac arrest (tc) under the influence of verapamil (V) or carbachol (C). 1. V caused a dose-dependent negative inotropic effect and an elevation of mic and tc for either glycoside. The elevation of mic and tc could be cor~elated positively to the degree of +he negative inotropic effect of V. 2. Also C caused a dose-dependent negative inotropic effect and likewise elevated mic and tc o~ D. 3. O '"M in lxCa -+ as wasi~he elevaßion of mic and tc for Dt. c and tc for D. 4. cating a coii1JTion mechanism of action of 1.
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