By Mark R. Wick MD, James W. Patterson MD
Neoplastic mimics or ìpseudotumorsî can simulate neoplasms on all degrees of analysisóclinical, radiologic, and pathologicóand hence characterize specific diagnostic pitfalls for the pathologist that may eventually bring about healing misdirection.
Hundreds of colour photographs and research of diagnostic mimics advisor the pathologist via spotting and distinguishing the weird editions, morphologic anomalies, and deceptive good points that can simply result in an misguided interpretation and neglected prognosis. on the grounds that a few of the entities defined are unusual, Neoplastic Mimics in Dermatopathology emphasizes imaging and medical correlations all through to aid the pathologist as advisor to the complete diagnostic and medical administration staff. each pathologist who sees epidermis circumstances will locate this e-book a useful operating device to make sure exact analysis.
This ebook offers the pathologist with exact morphologic descriptions and diagnostic information in spotting those neoplastic mimics as they ensue within the pores and skin. moreover, descriptions and diagnostic assistance are supplied for the diversity of pores and skin lesions that could mimic benign lots yet are actually neoplastic. in the course of the ebook comparisons of neoplastic mimics with actual neoplasms are supplied, at medical, gross, and histologic degrees. within the presentation of each entity, the issues that give a contribution to differential analysis are emphasised.
Neoplastic Mimics in Dermatopathology Features:
- Over four hundred top quality photos exhibit the entire diversity of nonneoplastic and neoplastic mimics in pores and skin
- Concise, particular textual content descriptions to make the e-book effortless to exploit as a visible reference
- Expert authors advisor the reader to spotting and distinguishing deceptive specimens
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"Neoplastic mimics or ìpseudotumorsî can simulate neoplasms on all degrees of analysisóclinical, radiologic, and pathologicóand therefore symbolize specific diagnostic pitfalls for the pathologist that may finally bring about healing misdirection. countless numbers of colour pictures and research of diagnostic mimics advisor the pathologist via spotting and distinguishing the bizarre versions, morphologic anomalies, and deceptive beneficial properties which may simply bring about an faulty interpretation and overlooked prognosis.
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Additional resources for Neoplastic Mimics in Dermatopathology
The proliferating keratinocytes form broad “tongues” of invaginating epithelium, and these often have irregular interfaces with adjacent dermal stroma (208,210). Â�However, it is notable that there is no localized eosinophilia, fibromyxoid change, desmoplasia, or lymphatic or perineural permeation in PCH. 6). indd 17 15/01/13 11:05 PM 18â•… NEOPLASTIC MIMICS IN DERMATOPATHOLOGY Nucleoli and mitoses are variably seen in both PCH and Â�carcinomas; thus, they cannot be Â�reliably used in differential diagnosis.
Diagnostic Â� use of a generic term such as “atypical squamous proliferation” (ASP) is apropos in such circumstances. EPIDERMAL NEVI AND “DER WULST” Epidermal nevi (EN) are congenital malformations of the surface Â�wepithelium. 15). EN may be associated with other malformative lesions of the nervous system, eyes, bones, heart, and blood vessels (251–254). 16). As its name implies, the form of epidermal nevus known as “ichthyosis hystrix” simulates true ichthyosis, and is typified by bilateral or systematized cutaneous hyperkeratotic patches (257).
Pathologic reports in such cases may include a disclaimer stating that the specified association may exist but cannot be adequately assessed, making a deeper biopsy desirable. 13â•… Proliferating verrucae show obvious viropathic cytological features, including Â�homogenization and “clearing” of nuclear chromatin, perinuclear Â�cytoplasmic lucency, and clumping of keratohyaline Â�granules. The acanthotic epidermal profiles at the Â�periphery of these lesions often show inward Â�“bowing” toward the lesional center.
Neoplastic Mimics in Dermatopathology by Mark R. Wick MD, James W. Patterson MD